Of all the resources I found , I think that the following information from HAMS.cc sums up best how Naltrexone works with the Sinclair Method... "Naltrexone has been shown to be highly effective in helping people to moderate their drinking or to quit when it is used according to the Sinclair method also known as pharmaceutical extinction . In pharmacological extinction (also known as the Sinclair Method) one always takes a dose of naltrexone (50 mg) an hour before drinking alcohol . One never takes naltrexone unless one intends to drink. Pharmacological extinction works because alcohol addiction is an example of operant conditioning. When you drink alcohol, endorphins are released and reinforce the drinking behavior. Drinking is learned behavior. More precisely, drinking is an example of operant conditioning. Operant conditioning is normally a good thing because it helps us to learn new behaviors needed for survival. However, in the case of alcohol addiction it has led us ...